Transformative scientific research
At Eidos Therapeutics, we believe that providing optimal therapies for ATTR requires a clear understanding of its root cause. Thanks to decades of thoughtful experiments by researchers across the globe, we now have a detailed understanding of the mechanism of ATTR disease pathophysiology.
Eidos is dedicated to applying this knowledge to prevent, or even halt, the advancement of ATTR.
Native biology of TTR
TTR is a naturally occurring abundant protein that is named for its known roles in transporting thyroxine (thyroid hormone) and retinol (Vitamin A). TTR is normally produced by the liver, circulates as a tetramer in the blood, and returns to the liver and other tissues to be cleared.
TTR is highly evolutionarily conserved . Its role as an important transporter protein is critical to the function of multiple organ systems, including kidneys, eyes, bones, heart, and muscles. None of the documented human TTR variants result in a lack of the protein, suggesting that it may be required for healthy development or survival. The long-term consequences of reducing TTR levels in humans are unknown.